Comparison of Safety and Efficacy of Detaenial Sigmoid Neobladder and Ileal Neobladder

Launched by ZHUJIANG HOSPITAL · Apr 5, 2017

Keywords

ClinConnect Summary

This clinical trial is comparing two different surgical methods for creating a new bladder in patients with bladder cancer. The two methods being studied are the traditional ileal neobladder, which involves using a part of the intestine, and the newer detaenial sigmoid neobladder, which uses a different part of the intestine and is thought to have fewer complications. The goal of the trial is to find out which method is safer and more effective in helping patients regain urinary function after surgery.

To participate in this trial, you need to have certain types of bladder cancer and have already received some form of chemotherapy. If you are interested, you will be carefully evaluated by a urologist to make sure you're a good fit for the study. Participants can expect to receive close monitoring throughout the trial to assess their recovery and any side effects. This study is important because it aims to provide clear information on the best surgical options for patients needing a new bladder, helping to improve their quality of life after treatment.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Bladder carcinoma in situ, include CIS and T1G3 tumor, muscle invasive bladder cancer（T2/T3N0-1M0）
• • 2. Recurrent bladder cancer
• • 3. Other conditions that have been approved by a urologist for indications for new bladder surgery
• • 4. Had been received intravesical chemotherapy, intra-arterial infusion chemotherapy or systemic chemotherapy in the past.
• • 5. Voluntarily signed the informed consent -
• Exclusion Criteria:
• • 1. Preoperative serum creatinine more than 2.26mg/dl（Or 200μmol/L）
• • 2. Cancer invaded urethral (confirmed by the pathology)
• • 3. Non - bladder cancer patients underwent neobladder
• • 4. A history of other malignant tumors within five years
• • 5. Ileum / sigmoid chronic inflammation, like ulcerative colitis or intestinal tuberculosis, and so on.
• • 6. Other conditions that have been approved by a urologist for not suitable for new bladder surgery
• • -