Modulating Oscillations and Working Memory in Patients With Subdural Electrodes
Launched by UNIVERSITY OF NORTH CAROLINA, CHAPEL HILL · Apr 6, 2017
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
The aim of this study is to characterize the entrainment of endogenous neural oscillatory activity using direct electrical stimulation (DES) of the brain and understand the effects on cognition.
In this study, the investigators will apply rhythmic DES to patients who are undergoing routine DES for cortical mapping as a part of their epilepsy surgery evaluation with the aim of entraining cortical neural oscillations at specific frequencies relevant to cognitive processing and neuropsychiatric disease. The investigators hypothesize that rhythmic DES within a naturally occurring oscillatory f...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • 1. History of medically intractable epilepsy
- • 2. Capable of giving informed consent
- • 3. Aged 18 - 80 years, either sex
- Exclusion Criteria:
- • 1. Past or current history of other neurological illnesses including ischemic stroke, intracerebral hemorrhage, brain neoplasm.
- • 2. Major systemic illness
- • 3. Severe cognitive impairment defined as mini-mental state examination of less than 20
- • 4. Severe psychiatric illness
- • 5. Excessive use of alcohol or other substances
About University Of North Carolina, Chapel Hill
The University of North Carolina at Chapel Hill (UNC) is a leading research institution renowned for its commitment to advancing health and science through innovative clinical trials. With a robust infrastructure that supports multidisciplinary collaboration, UNC conducts cutting-edge research across various fields, including medicine, public health, and biomedical sciences. The university is dedicated to improving patient care and health outcomes by translating its research findings into practical applications. UNC’s clinical trials are designed to evaluate new therapies, interventions, and technologies, ensuring that they meet the highest ethical and scientific standards while fostering a culture of inclusivity and community engagement.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Patients applied
Trial Officials
Flavio Frohlich, PhD
Principal Investigator
University of North Carolina, Chapel Hill
Hae Won Shin, MD
Principal Investigator
University of North Carolina, Chapel Hill
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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