Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis

Launched by NATIONAL JEWISH HEALTH · May 5, 2017

Keywords

ClinConnect Summary

This clinical trial is focused on understanding sarcoidosis, a condition that causes inflammation and can affect various organs, especially the lungs. Researchers are particularly interested in how changes in genes and the environment might influence the immune system's response in people with sarcoidosis. By studying immune cells from participants, the team hopes to identify specific markers that could help to better diagnose and treat the disease in the future.

To be eligible for this trial, participants should be between 18 and 85 years old and have a confirmed diagnosis of sarcoidosis, either through a biopsy or through typical symptoms. Those who suspect they have sarcoidosis and are scheduled for a biopsy may also qualify. However, individuals who are currently smoking, have recently used certain medications that suppress the immune system, are pregnant, or cannot participate in the study procedures will not be included. Participants can expect to undergo some tests and procedures to help researchers gather important information about their immune system and how it relates to sarcoidosis. This study aims to improve our understanding of the disease and potentially lead to better treatment options in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Between the ages of 18 and 85
• • Diagnosis of sarcoidosis confirmed by either biopsy or by manifestations consistent with acute sarcoidosis in absence of other known diagnosis.
• • Have a suspected diagnosis of sarcoidosis and is scheduled to undergo a biopsy procedure to confirm a diagnosis of sarcoidosis.
• • Able to tolerate and willing to undergo study procedures
• Exclusion Criteria:
• • Current cigarette smoking or smoking within six months prior to the study
• • Currently or recently (\<6months) on immunosuppressive therapy
• • Pregnancy
• • Patient inability to participate in the study, such as undergo venipuncture and or BAL