Selinexor Plus Combination Chemotherapy in Treating Patients With Advanced B Cell Non-Hodgkin Lymphoma

Launched by BARBARA ANN KARMANOS CANCER INSTITUTE · May 9, 2017

Keywords

ClinConnect Summary

This clinical trial is studying a new treatment approach for patients with advanced B-cell non-Hodgkin lymphoma, including types like diffuse large B-cell lymphoma and others. The trial combines a drug called Selinexor with a standard chemotherapy treatment known as R-CHOP. Researchers aim to find the best dose of Selinexor that can be safely used with R-CHOP and see if this combination works better than R-CHOP alone in treating these types of lymphoma.

To participate in this trial, patients need to have a confirmed diagnosis of advanced B-cell non-Hodgkin lymphoma and meet specific health criteria, such as having measurable disease and a life expectancy of over six months. This trial is open to adults of all ages and backgrounds. Participants will receive the study treatment and will be monitored for its effects. It's also important to note that women who can become pregnant must use effective birth control during the trial. Overall, this study hopes to find a more effective treatment option for those battling this type of cancer.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Phase 1 Part: Patients with pathologically confirmed advanced stage B-cell NHL (Ann Arbor stage 3 or 4) for whom R-CHOP is considered appropriate therapy; newly diagnosed DLBCL, newly diagnosed low grade B cell NHL, and previously treated low grade B cell NHL patients in first relapse after a prior treatment with non-anthracycline containing chemotherapy are allowed; double hit and transformed diffuse large B cell lymphoma are allowed
• • \* Allowed low grade B cell lymphomas will include follicular lymphoma any grade, marginal zone lymphoma including mucosa-associated lymphoid tissue (MALT) lymphoma, indolent mantle cell lymphoma and Waldenstrom's macroglobulinemia
• • Phase 2 Part: Patients with pathologically confirmed newly diagnosed diffuse large B cell lymphoma (Ann Arbor stage 3 or 4); newly diagnosed double hit and transformed diffuse large B cell lymphoma are allowed
• • Patients must have measurable disease, defined as at least one lesion above and below the diaphragm or stage 4 disease that can be accurately measured in at least one dimension; lymph nodes should be considered abnormal if the long axis is \> 1.5 cm, regardless of the short axis
• * Allowed prior therapy:
• • Newly diagnosed DLBCL and low grade B cell lymphoma: No prior therapy is allowed except steroids equivalent to maximum of prednisone 20 mg once daily for maximum of seven days prior to registration
• • Relapsed/refractory low grade B cell lymphoma (only allowed in phase I): A minimum and maximum of one line of prior non-anthracycline containing therapy is allowed; prior localized radiation therapy is not considered a line
• • For patients who have had prior chemotherapy or immunotherapy, at least 2 weeks must have elapsed between last dose and initial dose of RCHOP-selinexor; for patients treated with radio-immunotherapy, at least 12 weeks
• • All races and ethnic groups are eligible for this trial
• • Eastern Cooperative Oncology Group (ECOG) performance status =\< 1 (Karnofsky \>= 60%)
• • Life expectancy of greater than 6 months
• • Premenopausal female patients of child-bearing potential must agree to use dual methods of contraception and have a negative serum pregnancy test at screening, and male patients must use an effective barrier method of contraception if sexually active with a female of child-bearing potential; acceptable methods of contraception are condoms with contraceptive foam, oral, implantable or injectable contraceptives, contraceptive patch, intrauterine device, diaphragm with spermicidal gel, or a sexual partner who is surgically sterilized or post-menopausal; for both male and female patients, effective methods of contraception must be used throughout the study and for three months following the last dose
• • Ability to understand and the willingness to sign a written informed consent document
• Exclusion Criteria:
• • Patients with DLBCL who have received chemotherapy or immunotherapy (except one week of steroids as described above) at any time point in the past for therapy of the DLBCL; patients with low grade B cell lymphomas who have received more than one prior line of chemotherapy or any anthracycline-containing therapy in the past for their low grade B cell lymphoma; localized radiation therapy does not count as a line of therapy
• • Patients who are receiving any other investigational agents
• • Patients with known brain metastases are excluded
• • History of severe allergic reactions (as determined by treating physician) attributed to the drugs being used in the study
• • Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, congestive heart failure (New York Heart Association \[NYHA\] class \>= 3 or left ventricular ejection fraction \< 45%), unstable angina pectoris, myocardial infarction within the last 3 months, clinically significant cardiac arrhythmia (i.e., ventricular tachycardia on anti-arrhythmia are excluded; 1st degree atrioventricular \[AV\] block or asymptomatic left anterior fascicular block \[LAFB\]/right bundle branch block \[RBBB\] permissible), or psychiatric illness/social situations that would limit compliance with study requirements
• • Pregnant and lactating women are excluded
• • Human immunodeficiency virus (HIV)-positive patients regardless of treatment are excluded; patients with evidence of active hepatitis B and hepatitis C infection with positive real time polymerase chain reaction (qPCR) are also excluded but patients with prior exposure to hepatitis B or C with negative qPCR are allowed
• • Patients with severe intolerance to glucocorticoids
• • Major surgery within 2 weeks of first dose of study drug
• • Patients who are unable to swallow tablets, patients with malabsorption syndrome, or any other gastrointestinal (GI) disease or GI dysfunction that could interfere with absorption of study treatment
• • Absolute neutrophil count (ANC) \< 1500 cells/mm\^3
• • Platelet count \< 100,000/mm\^3
• • Serum bilirubin \> 1.5 times the upper limit of normal (ULN) (except patients with Gilbert's syndrome: total bilirubin of \> 3 x ULN)
• • Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \> 2.5 times ULN
• • Estimated creatinine clearance of \< 30 mL/min, calculated using the formula of Cockroft and Gault