Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury

Launched by JOHNS HOPKINS UNIVERSITY · May 9, 2017

Keywords

ClinConnect Summary

This clinical trial is studying a medication called tesamorelin to see if it can help people recover better and faster after surgery for peripheral nerve injuries, specifically injuries to the ulnar nerve at the wrist. Researchers believe that tesamorelin might improve both movement and feeling in the affected areas. Participants in the trial will be randomly assigned to receive either tesamorelin or a placebo, which is an inactive substance that looks like the real drug but has no effect. Over the course of a year, the researchers will conduct monthly tests to check how well the nerves are healing and how much function and sensation are improving.

To be eligible for this trial, participants should be between the ages of 65 and 74 and have had a recent surgical repair of an ulnar nerve laceration at the wrist. However, certain individuals will not be able to participate, including those with specific past or current cancers, uncontrolled diabetes or high blood pressure, certain pituitary issues, or those who are pregnant or have substance abuse problems. Throughout the study, participants can expect regular evaluations to monitor their recovery and to contribute to important research that could help improve treatments for nerve injuries in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Ulnar nerve laceration at the wrist, repaired primarily
• Exclusion Criteria:
• • Certain cancers (active or in the past)
• • Uncontrolled diabetes or hypertension
• • Certain pituitary problems
• • Oral contraceptives
• • Pregnancy
• • Drug or alcohol dependence
• • Psychosocial issues that would limit participation and compliance