Vessel Wall Imaging for Diagnosis and Monitoring of Central Nervous System (CNS) Vasculitis

Launched by MAYO CLINIC · May 23, 2017

Keywords

ClinConnect Summary

This study will evaluate patients with suspected primary angiitis of the central nervous system (PACNS), recruited during initial work-up by our multi-disciplinary team. Given the low incidence of CNS vasculitis and the fact that some patients are routed to a quaternary care center after initial work-up and diagnosis, evaluation of both groups will be useful to maximize the number of participants evaluated and to provide a representative sample of patients typically treated. During the study, participants will ultimately be deemed to have;

1. A specific clinical and pathologic subtype of P...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. The patient is determined to have suspected PACNS upon evaluation by a neurologist or rheumatologist or may have an established diagnosis of PACNS of any duration as determined by a neurologist or rheumatologist.
• • 2. Ability to undergo routine clinical testing, including lumbar puncture performed for PACNS to exclude potential alternative diagnoses (for initial suspected cases).
• • 3. Ability to provide informed consent.
• Exclusion Criteria:
• • 1. Less than 18 years of age.
• • 2. Any absolute contraindication to 3 Tesla MRI.
• • 3. Any absolute contraindication to gadolinium.
• • 4. Contraindication to lumbar puncture such as severe coagulopathy.
• • 5. High risk carotid atherosclerotic plaque defined as either greater than 70% stenosis or known high risk plaque features such as intra-plaque hemorrhage.
• • 6. Medium or high risk factors for cardioembolic stroke based on the Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria.