Cardiac Functions as a New Method for Evaluation of Fetal Anemia Pre and Post Intrauterine Fetal Blood Transfusion
Launched by NATIONAL RESEARCH CENTRE, EGYPT · May 25, 2017
Trial Information
Current as of August 20, 2025
Completed
Keywords
ClinConnect Summary
INTRODUCTION
Circulatory changes associated with fetal anemia have an important role in maintaining sufficient tissue oxygenation. With fetal anemia, hyperdynamic circulation and increased cardiac output occurred. This is due to reduced the viscosity of blood, increased the contractility of heart, and peripheal vasodilatation due to hypoxia. In current practice, using Doppler in assessment of the peak systolic velocity (PSV) of the middle cerebral artery (MCA) is the main parameter in screening of fetal anemia. Severe fetal anemia causes continuous loss of adaptive mechanisms due to lack o...
Gender
FEMALE
Eligibility criteria
- Inclusion Criteria:
- • Rh isoimmunized patients (positive titre of indirect coomb's test) who are scheduled to have intrauterine blood transfusion.
- Exclusion Criteria:
- • Less than 15 weeks gestational age and more than 28 weeks gestational age
- • fetuses with structural or functional Fetal or echocardiographic anomalies.
About National Research Centre, Egypt
The National Research Centre (NRC) in Egypt is a leading institution dedicated to advancing scientific research and innovation across various disciplines, including health and medicine. Established to support national development, the NRC conducts cutting-edge clinical trials aimed at improving public health outcomes and addressing pressing medical challenges. With a commitment to ethical research practices and collaboration with local and international partners, the NRC plays a pivotal role in fostering advancements in medical science, contributing to evidence-based healthcare solutions, and enhancing the quality of life for communities in Egypt and beyond.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Cairo, , Egypt
Patients applied
Trial Officials
Ahmad Z El Sheikhah, Professor
Principal Investigator
Professor of Obstetrics and Gynecology, Cairo Fetal Medicine Unit, Cairo University
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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