Multi-Parametric MRI for Renal Transplantation

Launched by UNIVERSITY OF MINNESOTA · Jun 16, 2017

Keywords

ClinConnect Summary

This clinical trial is studying how different types of MRI (Magnetic Resonance Imaging) can help assess kidney function in patients who have received a kidney transplant. The researchers want to see if MRI can show how well the transplanted kidney is working and if it can help identify why kidney function might decline. They will also look at how MRI can measure changes in kidney function before and after treatment when problems arise.

To participate in this trial, you need to be a kidney transplant recipient who can speak English and give consent. You may be eligible if you have had a sudden drop in kidney function or if your kidney function has stabilized after treatment. Participants will undergo MRI exams using either a 3T or a more powerful 7T MRI scanner, and some may have multiple sessions. It's important to note that certain medical conditions or devices, such as certain types of implants, pacemakers, or severe claustrophobia, may prevent you from participating. This study is not yet recruiting participants, but it aims to improve how we monitor and treat kidney function after transplantation.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Renal Transplant Recipients
• • Capable to consent
• • English speaking
• • For studies with patients with fast worsening renal function: An abrupt (within 48 h) reduction in kidney function currently defined as a percentage increase in serum creatinine of ≥50% (1.5-fold from baseline), or a reduction in urine output (documented oliguria of less than 0.5 mL/kg/h for more than 6 h).
• • For patients with recovered renal allograft function after therapy: renal allograft function as measured by glomerular filtration rate (eGRF) has been recovered and stabilized above a clinical acceptable level, such as 15 ml/min/1.73 mm2.
• Exclusion Criteria:
• • On dialysis due to renal allograft failure
• • Acute and chronic pulmonary disease
• • Pregnancy as reported in CMRR Safety Screen
• • Ferromagnetic implants
• • Any foreign metal objects in the body
• • History of shrapnel or shot gun injury
• • Cardiac pacemakers
• • Defibrillator
• • Neuronal stimulator
• • Magnetic aneurysm clip
• • Large tattoos on the abdomen or the brain and neck, as determined by CMRR Safety Officer
• • Hip replacement
• • Too large to fit in the magnet (BMI \>= 40, approx.)
• • Severe claustrophobia