NIAID Centralized Sequencing Protocol

Launched by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (NIAID) · Jun 30, 2017

Keywords

ClinConnect Summary

The NIAID Centralized Sequencing Protocol is a clinical trial that aims to better understand the genetics behind immune disorders, such as allergies, autoimmune diseases, and primary immunodeficiencies. Researchers will analyze DNA from participants, which can be collected from blood, saliva, or other tissue samples. By studying these genetic differences, they hope to identify important information that may help in managing health conditions and provide insights into the risks for serious diseases.

To be eligible for this trial, participants need to be involved in another NIH research study or be related to someone who is. This includes individuals of all ages, from newborns to seniors, who are willing to undergo genetic testing and allow their samples to be stored for future research. Participants can expect to receive meaningful results that may impact their health, although some findings might not be significant. It's important to know that personal information will be kept confidential, and if new studies arise, participants may be contacted for additional information.

Gender

ALL

Eligibility criteria

• * PARTICIPANT INCLUSION CRITERIA:
• * Must fulfill one of the following criteria:
• • Proband participants: must be individuals under investigation by another NIH protocol on which they are co-enrolled, or are referred from the GDMCC protocol "Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults" (NCT04702243). Probands may have a disease under investigation or be healthy volunteers
• • Biological relatives: biologically related to a proband participant.
• • Aged 0-99 years.
• • Participants must be willing to undergo genetic testing.
• • Participants must be willing to allow samples to be stored for future research.
• • Participants must be willing to have their de-identified genomic data shared, for example in a controlled access databases like the Database of Genotypes and Phenotypes (dbGaP).
• * To complete surveys and interviews:
• • Proficient with the English language.
• • Able to provide informed consent.
• • Adult healthy volunteers must be able to provide informed consent.
• PARTICIPANT EXCLUSION CRITERIA:
• • Any condition that, in the opinion of the investigator, contraindicates participation in this study is a reason for exclusion.