Improving Hypertension Control in CHina and ARGEntina With a Mobile APP-based Telecare System

Launched by ISTITUTO AUXOLOGICO ITALIANO · Jun 30, 2017

Keywords

ClinConnect Summary

The CHARGE-APP trial is exploring a new way to help people control high blood pressure (hypertension) using a mobile app called the ESH CARE app, combined with regular doctor visits. The goal is to see if this approach leads to better blood pressure management compared to standard care alone. The study will look at how well participants' blood pressure is controlled over one year and assess other health markers related to heart and kidney health.

To participate, individuals need to be between 18 and 80 years old and have high blood pressure that isn’t well managed. They should also have access to a smartphone that can use the app. However, those with certain serious health conditions, like severe kidney issues or unstable medical problems, won’t be eligible. Participants can expect to engage with the app and attend regular check-ups to track their progress throughout the study. This trial aims to find out if using technology can improve health outcomes for people with high blood pressure.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Male and female subjects;
• • Age 18-80 years;
• • Either the patient or another person close to him/her should possess a smartphone compatible with the ESH CARE app and be capable of using it;
• • Uncontrolled (untreated or treated) hypertension, defined as office BP ≥140/90 mmHg, and Ambulatory 24h ABP ≥130/80 mmHg
• Exclusion Criteria:
• • eGFR \<45 mL/min/1.73 m2 (CKD-EPI creatinine equation 2009);
• • Severe uncontrolled hypertension (i.e. BP ≥200/120 mmHg despite treatment);
• • Known secondary hypertension;
• • Orthostatic hypotension (SBP fall \> 20 mmHg on standing);
• • Unstable clinical conditions or severe disease with short life expectation;
• • Known atrial fibrillation;
• • Hepatic disease as determined by either AST or ALT values \> 2 times the upper limit of normal;
• • History of gastrointestinal surgery or disorders which could interfere with drug absorption
• • History of malignancy including leukaemia and lymphoma (but not basal cell skin cancer) within the last 5 years;
• • History of clinically significant autoimmune disorders such as systemic lupus erythematosus;
• • History of drug or alcohol abuse within the last 5 years;
• • History of non-compliance to medical regimens and/or patients who are considered potentially unreliable;
• • Dementia (clinical diagnosis);
• • Inability or unwillingness to give free informed consent;
• • Inability to use even simple communication technologies;
• • Pregnancy or planned pregnancy during study period