Distribution of Lymph Node Metastases in Esophageal Carcinoma

Launched by ACADEMISCH MEDISCH CENTRUM - UNIVERSITEIT VAN AMSTERDAM (AMC-UVA) · Jul 17, 2017

Keywords

ClinConnect Summary

The TIGER study is researching how cancer spreads to the lymph nodes in patients with esophageal cancer. Lymph nodes are small glands that help fight infections, but when cancer spreads to them, it can affect a patient's chances of recovery. The study aims to understand the patterns of lymph node involvement based on factors like where the tumor is located, its type, how deep it has invaded, and any treatments the patient has received before surgery. This information will help doctors create more effective, personalized treatment plans for patients.

To participate in this study, patients should have a specific type of esophageal cancer that can be surgically removed and be in good enough health to undergo surgery. The study is open to all adults, typically aged between 65-74, but younger patients may also qualify. Participants will undergo a surgical procedure called transthoracic esophagectomy, where the cancerous part of the esophagus is removed, along with nearby lymph nodes. These nodes will then be examined to gather important data about cancer spread. Overall, the findings from this study could lead to improved treatment strategies tailored to individual patients' needs.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Primary squamous cell or adenocarcinoma of the esophagus or esophago-gastric junction
• • Surgically resectable (cT1-4a, N0-3, M0)
• • Adequate physical condition to undergo transthoracic surgery (ASA 1-3)
• • Transthoracic esophagectomy
• Exclusion Criteria:
• • Previous thoracic or abdominal (upper GI) surgery disturbing lymph drainage of the esophagus and stomach
• • Patients with in situ carcinoma or high grade dysplasia