Antibiotics vs. Placebo in Acute Uncomplicated Appendicitis
Launched by TURKU UNIVERSITY HOSPITAL · Jul 26, 2017
Trial Information
Current as of June 26, 2025
Enrolling by invitation
Keywords
ClinConnect Summary
Acute appendicitis is the most common cause of abdominal pain in emergency departments and appendectomy is the most common emergency abdominal surgery. The lifetime risk of acute appendicitis in males is 8.6% and 6.7% in females.In Finland according to Stakes data there were 6 377 appendectomies (3242 in males, 3135 in females, median age 35 years) performed in 2010 with a total number of days in hospital care was 16 111 days and the mean length of hospital stay was three days.
Although acute appendicitis is the most common reason for surgical emergency department visit, its diagnosis stil...
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age between 18-60 years
- • CT confirmed uncomplicated acute appendicitis
- • Ability to give informed consent
- Exclusion Criteria:
- • Age under 18 or over 60 years
- • Pregnancy or lactation
- • Allergy to contrast media or iodine
- • Allergy or contraindication to antibiotic therapy
- • Metformin medication
- • Renal insufficiency
- • Severe systemic illness (for example malignancy, medical condition requiring immunosuppressant medication)
- • Complicated acute appendicitis confirmed by CT scan
- • Inability to cooperate or give informed consent
About Turku University Hospital
Turku University Hospital (TYKS) is a leading academic medical center located in Turku, Finland, renowned for its commitment to advancing healthcare through innovative research and clinical excellence. As a key institution within the University of Turku, TYKS integrates cutting-edge medical education with state-of-the-art clinical services, offering a broad spectrum of specialized care. The hospital actively participates in clinical trials, facilitating the translation of scientific discoveries into practical treatments, and enhancing patient outcomes. With a multidisciplinary approach and a focus on collaboration, TYKS aims to contribute significantly to the global medical community through its rigorous research initiatives and commitment to patient-centered care.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Turku, , Finland
Patients applied
Trial Officials
Paulina Salminen, MD,PhD
Principal Investigator
Turku University Hospital
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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