PRIME: Cognitive Outcome Following Major Burns

Launched by CHELSEA AND WESTMINSTER NHS FOUNDATION TRUST · Aug 7, 2017

Keywords

ClinConnect Summary

Patients were matched with for age, sex and IQ (as determined by National Adult Reading Test scores) controlled volunteers.

Participants were assessed for the following domains: verbal ability, verbal and visual learning, short-term memory, working memory, executive function, attention and processing speed. The domains were assessed with the following validated cognitive tests: The Hopkins Verbal Learning Test, Trail making parts A and B, phonemic, semantic and switching verbal fluency as well as the Cogstate computerised battery: Identification speed, Detection speed, One Card Learning ac...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Invasive ventilation on a Burns Intensive Care Unit (BICU) within the previous ten years
• • Burn injuries greater than 15% total body surface area (TBSA)
• • Adult
• Exclusion Criteria:
• • Admission to BICU for other illnesses that were not burn related (such as Toxic Epidermal Necrolysis Syndrome)
• • Evidence of head trauma
• • Known substance misuse or alcohol excess
• • Inability to understand plain verbal or written English
• • Severe mental health issues
• • Receiving formal psychiatric treatment
• • Currently held under the Mental Health Act
• • If the subject's psychological health was deemed to be at risk from inclusion
• • Imprisoned
• • Contraindications to MRI
• • non-compatible pacemakers
• • surgical metalwork or foreign bodies
• • severe claustrophobia