Intensity-Modulated Stereotactic Radiation Therapy in Treating Patients With Grade II-IV Glioma

Launched by SIDNEY KIMMEL CANCER CENTER AT THOMAS JEFFERSON UNIVERSITY · Aug 14, 2017

Keywords

ClinConnect Summary

This clinical trial is looking at a new way to treat patients with certain types of brain tumors called gliomas, specifically those graded II to IV. The treatment being tested is called intensity-modulated stereotactic radiation therapy, which delivers a high dose of radiation directly to the tumor while aiming to minimize damage to the surrounding healthy tissue. This approach could potentially help patients recover better after treatment.

To participate in the trial, patients need to have a confirmed diagnosis of grade II to IV glioma, be recovering well from surgery, and have a reasonable level of overall health and expected survival. Participants should be between 65 and 74 years old and must agree to the study's requirements and guidelines. If eligible, patients can expect to begin radiation treatment within a specified time after surgery. It’s important to note that individuals with certain health issues, previous radiation treatments, or who are pregnant cannot take part in this study.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients must have histologically confirmed low or high grade glioma (grade II-IV)
• • Karnofsky performance status (KPS) \>= 60
• • Patients must have recovered from the effects of surgery; there must be a minimum of 21 days from the day of surgery to the day of protocol treatment
• • Estimated survival \>= 3 months
• • Labs considered acceptable per standard of care
• • Patient must sign a study specific informed consent form
• • Radiation treatment must begin \>= 3 weeks and =\< 8 weeks after surgery
• Exclusion Criteria:
• • Prior history of scalp radiation or intolerance to standard course of radiation treatment
• • Co-morbidities that would influence wound healing including diabetes (insulin dependent) or smoking (current ongoing use)
• • Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception
• • Karnofsky performance status (KPS) \< 60
• • Patient can't have magnetic resonance imaging (MRI) scan
• • Active collagen vascular disease