Detecting Transitional Cell Carcinoma From Haematuria

Launched by HULL UNIVERSITY TEACHING HOSPITALS NHS TRUST · Aug 17, 2017

Keywords

ClinConnect Summary

The effective diagnosis of transitional cell carcinoma (TCC), the most common form of bladder cancer, is often quite challenging, due to a lack of disease-specific symptoms. Detecting TCC early is crucial to increase the chances of a cure. Cystoscopy, which is currently the standard test used for urothelial cancer diagnosis, is an invasive and relatively expensive procedure but, while several potential markers in urine have been studied with the goal of replacing cystoscopy, no urinary marker alone or in combination with others has shown sufficient accuracy.

In this study, levels of tissue...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Capable of giving written informed consent
• • Age ≥18 years
• • Referral to haematuria clinic (gross or microscopic haematuria)
• Exclusion Criteria:
• • Inability to provide written informed consent
• • Previous radiotherapy to the bladder (e.g. prostate cancer)
• • Active urinary tract infection (Patients may be re-approached at later opportunity when urinary infection is cleared and haematuria persists)
• • Current or planned treatment with neoadjuvant chemotherapy or radiotherapy
• • Other known malignant condition, either active or in complete remission ≤5 years
• • HIV, hepatitis C, or any other known communicable disease