The Cholesterol-lowering Efficacy of Probiotic Lactobacillus Plantarum in Hypercholesterolaemic Adults

Launched by UNIVERSITY OF ROEHAMPTON · Aug 25, 2017

Keywords

ClinConnect Summary

The aim of this human volunteer study was to establish tolerance, and the extent of the cholesterol lowering potential of Lactobacillus plantarum ECGC 13110402 in 49, healthy, normal to mildly hypercholesterolaemic adults (30-65 years old).

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • aged between 18 and 50 years of age.
• • in good general health, defined as no comorbidities requiring regular
• • medical follow up
• • ability to communicate well with the investigator and to comply with the
• • requirements of the entire study
• • BMI 18.5 to 29.9 kg/m2
• • total cholesterol (TC) between 200 and 300 mg/dl (5.16 and 7.64 mmol/L).
• Exclusion Criteria:
• • History or evidence of organic disease of the gastrointestinal tract; such as tumour, irritable bowel syndrome, etc., within the previous 5 years
• • Consumed probiotic or prebiotic preparations on a regular basis (at least 3
• • times per week) in the last 2 weeks and during the trial period
• • Former participation in another study involving prebiotic or probiotic
• • preparations or investigational drugs within the previous 6 months, or
• • intention to use such drugs during the course of the study
• • high blood cholesterol or use of cholesterol lowering drugs
• • Undergone surgical resection of any part of the bowel
• • History of malignancy within the previous 5 years (with exception of well-
• • treated basal cell carcinoma or in situ cervical carcinoma).
• • Currently prescribed immunosuppressive drugs
• • Intention to use regularly other medication which affects gastrointestinal
• • motility and/or perception
• • Current or recent history (within 12 months) of significant drug or alcohol
• • abuse or dependence