Bedtime ACEIs/ARBs Versus Morning ACEIs/ARBs for Reverting Non-dipping Hypertension

Launched by CHINESE UNIVERSITY OF HONG KONG · Sep 13, 2017

Keywords

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Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients who are taking an ACEI or an ARB
• • \>18 years of age
• • Chinese and
• • Received a diagnosis of primary HT.
• Exclusion Criteria:
• • Severe HT as defined by a clinic systolic BP ≥180 mmHg and/or diastolic BP ≥ 110 mmHg
• • allergic reaction or intolerance to the current ACEI or ARB
• • unable to provide consent
• • pregnancy
• • night-time worker
• • occupational drivers since patients will be asked not to move during BP measurements, which may induce potential danger in driving
• • taking anti-coagulants to avoid causing bruises when using ABPM
• • known atrial fibrillation since ABPM use has not been validated in this group
• • known hyperkalemia
• • ABPM discovered hypotension (mean SBP \< 100 and/or mean DBP \< 60) because these patients may need to stop their medications
• • Reported sleep time of \<4 hours per night (at least seven readings are recommended during sleep for an ABPM recording to be valid, and a sleeping time \< 4 hours is unlikely to generate valid results).