Short Term Effects of Synchronized vs. Non-synchronized NIPPV in Preterm Infants.

Launched by UNIVERSITY OF TURIN, ITALY · Sep 18, 2017

Keywords

ClinConnect Summary

This clinical trial is studying how two different methods of breathing support—synchronized nasal intermittent positive pressure ventilation (SNIPPV) and non-synchronized NIPPV—affect the breathing and heart function of preterm infants (those born before 32 weeks of pregnancy) who are having trouble breathing. This trial is important because it aims to find out which method helps these babies better adapt to breathing on their own, especially when they are first being treated with this non-invasive breathing support right after birth or after being taken off a breathing machine.

To participate in the trial, infants need to be born before 32 weeks of pregnancy and have never received this type of breathing support before, or they should be getting it again after being on a breathing machine. Parents will need to give their consent for their child to join. Unfortunately, babies with certain health issues, like serious brain problems, infections, or major birth defects, cannot take part in this study. If enrolled, families can expect regular monitoring of the baby's heart and breathing responses while using the two different ventilation methods. This trial is currently recruiting participants to help improve care for preterm infants with breathing difficulties.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Gestational age at birth \<32 weeks
• • First approach to NIV ventilation (primary or after extubation)
• • Parent's informed consent
• Exclusion Criteria:
• • Neurological (including IVH \> 2° grade) or surgical diseases
• • Sepsis (clinical or laboratory confirmed)
• • Chromosomal or genetic abnormalities
• • Major malformations and congenital anomalies
• • Cardiac problems (including hemodynamically significant PDA)
• • Contraindication to NIV (i.e. nasal trauma and gastrointestinal surgery within the previous 7 days).