Morphology of Advanced Symptomatic Cerebral Plaques With High Embolic Potential

Launched by CHINESE UNIVERSITY OF HONG KONG · Sep 20, 2017

Keywords

ClinConnect Summary

This clinical trial is studying the early detection of unstable plaques in the brain that can lead to strokes in patients with a condition called intracranial atherosclerotic disease (IAD). These plaques can be dangerous because they have a high risk of breaking off and causing blockages in blood vessels, leading to strokes. The researchers aim to identify these risky plaques so that doctors can better manage and treat patients to prevent future strokes.

To participate in this study, you need to be between 30 and 85 years old. There are two groups in the trial: one group includes people who have recently had a stroke, and the other group includes those who have significant narrowing of the blood vessels in the brain but have not had a stroke. If you join the study, you will undergo certain imaging tests to help identify the condition of the plaques. It's important to know that you must not have any other medical issues that could complicate the study, and you will need to give your consent after understanding what the study involves. This trial is currently recruiting participants, so if you or someone you know fits the criteria, it might be a good opportunity to contribute to important research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• * Inclusion Criteria for the Symptomatic Group:
• • 1. Patient is 30 to 85 years of age, inclusive.
• • 2. Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism, a relevant intracranial atherosclerotic stenosis ≥60%, and MES detected by TCD.
• • 3. Patient who has no contra-indication for the proposed imaging tests.
• • 4. Patient understands the purpose and requirements of the study, and has provided an informed consent.
• * Inclusion Criteria for the Asymptomatic Group:
• • 1. Patient is 30 to 85 years of age, inclusive.
• • 2. Patient who has a high-grade (\>60%) intracranial stenosis (signal void in MR angiography) but without infarct in the corresponding vascular territory in DWI or T2-weighted sequence.
• • 3. Patient has no MES detected on TCD examination.
• • 4. Patient who has no contra-indication for the proposed imaging tests.
• • 5. Patient understands the purpose and requirements of the study, and has provided an informed consent.
• Exclusion Criteria:
• Subject who meets one or more of the following criteria cannot be recruited in the study:
• • 1. Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease, etc.
• • 2. A tandem stenosis \>50% at proximal internal carotid artery.
• • 3. Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \<100 x 109/L), coagulopathy (INR \>1.5).
• • 4. A medical condition that would not allow the patient to adhere to the protocol or complete the study.