Morphologic Evolution and Remodeling of Intracranial Atherosclerosis: A Longitudinal Study by 3D-rotational Angiography

Launched by CHINESE UNIVERSITY OF HONG KONG · Sep 25, 2017

Keywords

ClinConnect Summary

This clinical trial is looking at how certain changes happen in the blood vessels inside the brain, specifically focusing on conditions that can lead to strokes. The study aims to understand how atherosclerosis, which is the buildup of plaque in the arteries, evolves and changes over time, especially when patients are managing their heart health through lifestyle or medication. Researchers are using advanced imaging techniques to get a clear picture of these changes.

To participate, individuals must be between 30 and 85 years old and have experienced a specific type of stroke caused by a significant narrowing (60% or more) of an artery in the brain due to atherosclerosis. Participants should also be able to safely undergo the necessary imaging tests and provide informed consent. During the study, participants will undergo monitoring and imaging to track their condition over time. It's important to note that those with certain other medical conditions or specific types of strokes unrelated to atherosclerosis won't be eligible to join. This study is currently recruiting participants, so there is an opportunity for those who meet the criteria to contribute to important research that may help improve stroke care in the future.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient is 30 to 85 years of age, inclusive.
• • 2. Patients who have an acute infarct in diffusion-weighted MRI compatible with artery-to-artery thrombo-embolism and a relevant intracranial atherosclerotic stenosis ≥60%.
• • 3. Patient who has no contra-indication for the proposed imaging tests.
• • 4. Patient understands the purpose and requirements of the study, and has provided an informed consent.
• Exclusion Criteria:
• Patient with any of the following conditions would be excluded:
• • 1. Stroke etiology uncertain or unrelated to intracranial atherosclerosis, such as cardioembolism, Moyamoya disease, small vessel disease or primary angiitis of CNS.
• • 2. A tandem stenosis \>50% at extra-cranial internal carotid artery.
• • 3. Bleeding propensity: active peptic ulcer disease, major systemic hemorrhage within 30 days, thrombocytopenia (platelets \<100 x 109/L), coagulopathy (INR \>1.5).
• • 4. A medical condition that would not allow the patient to adhere to the protocol or complete the study.