Rapid Analysis of Infections by Spectrometry of Exhaled Breath

Launched by UNIVERSITAIRE ZIEKENHUIZEN KU LEUVEN · Sep 27, 2017

Keywords

ClinConnect Summary

This clinical trial is studying a new way to diagnose and understand respiratory infections in patients with certain blood disorders, like leukemia or anemia, who are receiving intensive chemotherapy. Researchers want to see if analyzing the breath of these patients using a special technique called spectrometry can help doctors identify infections faster and more accurately. This could be important for improving treatment and outcomes for these patients.

To participate in this study, patients must be at least 18 years old and have specific blood disorders, such as acute myeloid leukemia (AML) or aplastic anemia, and be undergoing certain treatments. They should not currently have signs of an active respiratory infection. If eligible, participants will provide written consent and may undergo breath analysis during their treatment. This trial is currently recruiting, and it aims to gather important information that could lead to better care for patients facing serious health challenges.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Age ≥ 18y at start of study
• * One of the following diagnoses:
• • De novo, refractory or relapsed AML/MDS receiving intensive chemotherapy
• • De novo, refractory or relapsed ALL/T-lymphoblastic lymphoma receiving intensive chemotherapy
• • Aplastic anemia requiring ATG therapy
• • Any patient admitted for either autologous hematopoietic stem cell transplantation. Transplantation may not have been performed at time of enrolment.
• • Any patient admitted with allogeneic hematopoietic stem cell transplantation within the last year, or planned during this admission.
• • Written informed consent obtained from the patient
• Exclusion Criteria:
• • Hematological disease beyond the specified inclusion criteria
• • Signs of active respiratory infection
• • If previously enrolled: incomplete clearance of all signs of respiratory infection (both clinically, microbiologically and radiologically).