Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits

Launched by IMPERIAL COLLEGE LONDON · Oct 5, 2017

Keywords

ClinConnect Summary

This clinical trial is investigating how well imaging techniques can help doctors identify cancer deposits in patients with suspected adenocarcinoma of the colon, sigmoid, or rectum. The goal is to see if using advanced imaging can improve the agreement between what doctors see on scans and what they find when examining tissue samples after surgery. Patients who are eligible for this trial are those aged 16 and older who have been diagnosed with adenocarcinoma through a biopsy and are scheduled for surgery. This includes patients who may have received treatment before their surgery.

If you participate in the trial, radiologists will map out the locations of lymph nodes and tumor deposits based on your pre-operative scans. This information will then be shared with pathologists who will analyze the tissue removed during your surgery. You will continue to receive standard follow-up care at your local hospital, and researchers will keep track of your health for five years after the trial. It’s important to note that patients with recurrent or multiple tumors, those under 16, or those who cannot provide informed consent are not eligible to participate.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Suspected primary adenocarcinoma of the colon, sigmoid or rectum (proven by biopsy taken as part of routine clinical practice, patients to be withdrawn if not subsequently adenocarcinoma on pathology).
• • 2. Amenable to surgical resection.
• • 3. Disease spread assessed on imaging
• • 4. Patients having primary surgery and those undergoing neoadjuvant treatment will be included.
• • 5. All must have had baseline staging scans and those undergoing neoadjuvant therapy must also have had a post-treatment scan.
• • 6. Patients aged 16 years and over
• Exclusion Criteria:
• • 1. Patients with recurrent tumours
• • 2. Synchronous tumours
• • 3. Under the age of 16 years
• • 4. Unable to give informed consent.