Arrhythmogenic Substrate in Primary Cardiomyopathies and/or Channellopathies

Launched by IRCCS POLICLINICO S. DONATO · Oct 3, 2017

Keywords

ClinConnect Summary

This clinical trial is exploring a procedure called catheter ablation to help prevent serious heart rhythm problems and sudden cardiac death in patients with specific heart conditions known as cardiomyopathy and channelopathies. The goal is to identify and remove areas of the heart that may cause dangerous arrhythmias (irregular heartbeats) in patients who already have an implanted device called an ICD (Implantable Cardioverter Defibrillator) to help monitor and control their heart rhythm.

To be eligible for this study, participants must be at least 18 years old and have a history of cardiomyopathy or channelopathies, such as long QT syndrome or J-wave syndrome. They should also have symptoms related to abnormal heart rhythms or have experienced documented episodes of these arrhythmias. Participants will be asked to attend follow-up appointments and provide their consent to join the trial. It's important to note that this study is not for pregnant or breastfeeding individuals, or those who may not have a life expectancy of more than 12 months. If you or a loved one meet these criteria, this trial could offer a potential new approach to managing heart rhythm issues.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients affected by cardiomyopathies and/or channellopaties (long QT syndrome and J-wave syndrome) with and without documented family history of BrS;
• • Presence of symptoms attributable to VA and/or presenting documented arrhythmic episodes;
• • Patients with an ICD already implanted;
• • Patients referred to the centre for an electrophysiological study and indication for a potential concomitant radio-frequency catheter ablation (RFA) of ventricular tachycardia (VT) or ventricular fibrillation (VF);
• • Age ≥ 18;
• • Willingness to attend follow-up examinations;
• • Written informed consent for the participation in the trial
• Exclusion Criteria:
• • Pregnancy or breast-feeding;
• • Life expectancy \< 12 months