Immune Responses in Health Care Personnel

Launched by FINNISH INSTITUTE FOR HEALTH AND WELFARE · Oct 23, 2017

Keywords

ClinConnect Summary

This clinical trial, titled "Immune Responses in Health Care Personnel," is designed to learn more about how vaccinations against influenza work, especially for health care workers. Researchers want to understand how the immune system responds to the flu vaccine, including how well it protects against different strains of the virus, how long that protection lasts, and how repeated vaccinations affect immunity. This study will last for 10 years and aims to gather valuable information that could improve vaccine effectiveness for everyone.

To participate, individuals need to be health care or laboratory workers within a specific health care organization who have chosen to receive the seasonal flu vaccine. They should be in generally good health and willing to join the study during the flu season. However, those with certain health conditions, such as weakened immune systems, pregnant or breastfeeding individuals, or those currently sick, will not be eligible. Participants can expect to provide informed consent and may be asked to share their health information and vaccination experiences over the course of the study. This research could help enhance our understanding of flu vaccinations, ultimately benefiting both health care workers and the patients they serve.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Members of health care or laboratory personnel in HUS having decided to take the seasonal influenza vaccination by the routine occupational health care service
• • General good health as established by or volunteer's own statement
• • Written informed consent
• • Presumably able and willing to participate in the study during the starting influenza season
• Exclusion Criteria:
• • Any confirmed or suspected immunosuppressive or immunodeficient condition, including human immunodeficiency virus (HIV) infection.
• • Administration (longer than 14 days) of immunosuppressants or other immune- modifying drugs within 6 months before the vaccination; oral corticosteroids in dosages of 20 mg/day or more prednisolone or equivalent are excluded; inhaled or topical steroids are allowed.
• • Pregnancy or lactation
• • Acute disease at the time of enrolment (defined as the presence of a moderate or severe illness with or without fever)
• • Contraindication for influenza vaccination
• • Any other criteria which, in the investigator's or dedicated study staff member's opinion, would compromise the ability of a subject to participate in the study, a subject's well-being, or the outcome of the study