Effects of Variation of Sodium Dialysate in ICU

Launched by UNIVERSITY HOSPITAL, MONTPELLIER · Oct 27, 2017

Keywords

ClinConnect Summary

This clinical trial is studying how different levels of sodium in the dialysate (the fluid used in dialysis) can affect patients in the Intensive Care Unit (ICU) who have acute kidney injury (AKI) and need dialysis treatment. The researchers want to see if using a lower sodium level of 140 mmol/l in the dialysate, compared to the standard level of 145 mmol/l, can help patients tolerate the treatment better without causing extra fluid buildup, which can be dangerous for critically ill patients.

To participate in this trial, individuals must be over 18 years old, have AKI requiring dialysis, and have a specific health score indicating the severity of their condition. Participants will be randomly assigned to receive either the lower or standard sodium level during their dialysis sessions. The trial is currently recruiting participants, and it’s important for potential volunteers to know that they shouldn’t have certain health issues, like severe chronic kidney disease or be pregnant. Overall, this study aims to improve the safety and effectiveness of dialysis for ICU patients.

Gender

ALL

Eligibility criteria

• Inclusion criteria:
• • Age \> 18 years old
• • Acute kidney injury requiring renal replacement therapy
• • Dialysis type: on line sustained low efficiency dialy dialysis -filtration
• • SOFA score \> 5
• • Sodium serum level between 135 and 145mmol/l
• Exclusion criteria:
• • Chronic kidney disease stade IV ou V
• • Obstrutive acute kidney injury
• • Renal tansplantation in the year before ICU admission
• • Moribund with risk of death in the 48 hours
• • Vulnerable persons or protected persons
• • Pregnant or breastfeeding mother