Assessing Neurocognition After Cerebrovascular Intervention

Launched by UNIVERSITY OF CALIFORNIA, SAN DIEGO · Nov 13, 2017

Keywords

ClinConnect Summary

This clinical trial is studying how carotid artery diseases, which can limit blood flow to the brain, affect thinking and memory skills, also known as neurocognitive function. The researchers want to see how changes in blood flow and certain blood markers relate to cognitive abilities before and after a treatment called carotid stenting, which helps improve blood flow. Participants will undergo several tests to assess their cognitive function and will have imaging and blood tests done at two points before the treatment and two points after.

To be eligible for this study, participants must be over 18 years old and have ultrasound evidence of significant narrowing in their carotid arteries—this means either having a 50% or greater blockage with symptoms or a 70% or greater blockage without symptoms. People who are unable to undergo an MRI, need emergency treatment, or cannot understand the study's risks and benefits will not be included. If you join the study, you can expect to complete some cognitive assessments and provide blood samples at different stages during the research process, helping to improve understanding of how carotid disease affects brain function.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • patients \>18 years of age
• • ultrasound evidence of carotid stenosis; in which the patient has either 50% or greater symptomatic carotid stenosis or 70% or greater asymptomatic carotid stenosis.
• Exclusion Criteria:
• • 1. patients \<18 years of age
• • 2. patients with without compatibility for MRI
• • 3. patients requiring carotid stenting for reasons not related to long-standing stenosis
• • 4. patients requiring emergency carotid stenting for acute symptoms such as crescendo transient ischemic attacks, intolerance of physiologic blood pressure.
• • 5. Patients that do not have appropriate capacity (i.e. understand the risks and benefits associated with this study) or are unable to consent for themselves will not be included in this study.