Genetic Susceptibility to Listeriosis

Launched by INSTITUT PASTEUR · Nov 24, 2017

Keywords

ClinConnect Summary

The clinical trial titled "Genetic Susceptibility to Listeriosis" is studying a serious foodborne infection called listeriosis, which can be particularly dangerous for older adults, pregnant women, and those with weakened immune systems. Some younger patients under 40 years old are experiencing severe forms of this illness without any known risk factors, leading researchers to suspect that genetics may play a role in why some people are more susceptible to listeriosis. The goal of the study is to find out if certain genetic traits make someone more likely to develop this infection.

To participate in this study, patients must have a confirmed case of listeriosis, especially if they are younger than 40 and don't have other health issues. Family members of those patients may also be invited to join the study, helping researchers understand the genetic links. Participants will be asked to provide consent and may undergo tests to help identify any genetic factors related to listeriosis. This study is important because it could lead to better understanding and treatment of this rare but serious infection.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for patients with Listeriosis :
• • Microbiologically documented Listeriosis (either a severe form of listeriosis, or an atypical form of listeriosis, or less than 40 years old and without any co-morbidity identified)
• • Affiliated or beneficiary of a social security system
• • Informed and written consent
• Inclusion Criteria for volunteers related to patients with Listeriosis (after identifying a genetic susceptibility in the patient with Listeriosis) :
• • defined as father, mother, brother (s), sister (s), child (ren), grandparent (s), uncle (s), aunt (s), cousin (s), nephew (s), niece (s).
• • Affiliated or beneficiary of a social security system
• • Informed and written consent
• Exclusion Criteria for volunteers related to patients with Listeriosis:
• • Inability to consent