Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)

Launched by FONDATION OPHTALMOLOGIQUE ADOLPHE DE ROTHSCHILD · Nov 27, 2017

Keywords

ClinConnect Summary

The clinical trial titled "Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome" is studying how certain markers on the surface of eye cells change in people with severe dry eye syndrome. This condition causes extreme dryness and discomfort in the eyes, which can be very bothersome. The researchers want to see how these markers change before and after starting a treatment, helping to understand the condition better and potentially improve future treatments.

To participate in this study, you need to be at least 18 years old and have severe eye dryness, which can be assessed through specific tests. People who are currently using certain treatments for dry eyes or who have specific eye conditions may not be eligible. If you join the trial, you will undergo tests to evaluate your eye condition, and your experience will contribute to important research that could help others with similar eye issues in the future.

Gender

ALL

Eligibility criteria

• Patients:
• • Inclusion criteria
• • 18 years and over
• • Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes
• • Exclusion criteria
• • Treatment with topical ciclosporin
• • Autologous serum treatment
• • Wearer of scleral lenses
• • Known pregnancy or breastfeeding
• Control subjects:
• • Inclusion criteria
• • 18 years and over
• • Tear Break Up Time \> 5 seconds (fluorescein test)
• • Exclusion criteria
• • Wearer of contact lenses
• • Functional ocular signs
• • Anomalies of the ocular surface observed during examination with the slit lamp
• • Fluorescein staining of the ocular surface (cornea, conjunctiva)
• • Topical ocular treatment
• • Known pregnancy or breastfeeding