Sentinel Node Mapping in High Risk Endometrial Cancer

Launched by AC CAMARGO CANCER CENTER · Dec 4, 2017

Keywords

ClinConnect Summary

This clinical trial is looking into the best way to find and treat lymph nodes in women with high-risk endometrial cancer. Specifically, it will compare two approaches: one where doctors use a special technique called sentinel node mapping to locate key lymph nodes, and another where they do that mapping followed by a more extensive removal of nearby lymph nodes. The goal is to see if the additional step of removing more lymph nodes is necessary or if the mapping alone is enough for effective treatment.

Women between the ages of 65 and 74 who have certain types of high-risk endometrial cancer may be eligible to participate. This includes those with specific aggressive tumor types or significant invasion into the surrounding tissues. Participants will be randomly assigned to one of the two treatment groups, and they can expect thorough monitoring and support throughout the study. It’s important to note that women who have had previous surgeries for cancer or have spread of the disease beyond the uterus cannot take part in this trial. Your involvement could help improve treatment options for others in the future!

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • High grade histologies (endometrioid grade 3, serous, clear cell and carcinosarcoma)
• • Endometrioid grades 1 or 2 with myometrial invasion of ≥50%
• • Endometrioid grades 1 or 2 with cervical invasion
• • Clinically suitable to receive systematic lymphadenectomy
• • Consent statement
• Exclusion Criteria:
• • Previous hysterectomy in other institution
• • Presence of extra-uterine disease (peritoneal, visceral or suspicious lymph node metastasis)
• • Previous pelvic node dissection