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Search / Trial NCT03373721

Gut Microbiota of Preterm Infants and Full-term Infants at Early Life

Launched by XINHUA HOSPITAL, SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE · Dec 11, 2017

Trial Information

Current as of July 24, 2025

Recruiting

Keywords

ClinConnect Summary

This clinical trial is studying the gut bacteria (microbiota) of preterm infants (born before 37 weeks of pregnancy) compared to full-term infants (born after 37 weeks) during their first 90 days of life. Researchers want to understand how the gut microbiome develops in these two groups and to identify factors that might influence this process. They believe that the way the gut bacteria progress in preterm infants may be different due to factors like antibiotic use, which can disrupt healthy gut development.

To participate in this study, preterm infants need to be at least 1 day old and have stayed in the hospital for more than 7 days without any serious gastrointestinal issues or metabolic diseases. The study also has a control group of healthy full-term infants who were born vaginally and do not have any gastrointestinal problems. Participants will be monitored as they grow, and their gut microbiome will be analyzed to gather important information about their health. This research aims to improve our understanding of gut health in newborns, especially those born early.

Gender

ALL

Eligibility criteria

  • Inclusion Criteria:
  • Preterm infants
  • 1. gestational age \<37 weeks;
  • 2. no gastrointestinal tract disorders, metabolic diseases, or viral hepatitis;
  • 3. hospital stay \> 7 days;
  • Exclusion criteria:
  • 1. NICU stay less than 7 days
  • 2. Necrotizing enterocolitis infant
  • Control group:
  • 1. Full-term healthy infants;
  • 2. gestational age \>37 weeks;
  • 3. vaginally born;
  • 4. no gastrointestinal tract disorders, metabolic diseases, or viral hepatitis.

About Xinhua Hospital, Shanghai Jiao Tong University School Of Medicine

Xinhua Hospital, affiliated with Shanghai Jiao Tong University School of Medicine, is a prominent clinical research institution renowned for its commitment to advancing medical science and patient care. Located in Shanghai, China, the hospital integrates clinical practice, education, and research, fostering innovation in various medical fields. With state-of-the-art facilities and a multidisciplinary team of experts, Xinhua Hospital conducts rigorous clinical trials aimed at evaluating new therapies and improving treatment outcomes. Its dedication to ethical standards and patient safety positions it as a leader in the global clinical research landscape.

Locations

Shanghai, , China

Patients applied

0 patients applied

Trial Officials

Jie Jia, PhD

Principal Investigator

Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Timeline

First submit

Trial launched

Trial updated

Estimated completion

Not reported

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