Volumetric Intensity Modulated Arc Therapy vs. Conventional Radiotherapy for Cancer Pain

Launched by CENTRE HOSPITALIER DE L'UNIVERSITÉ DE MONTRÉAL (CHUM) · Dec 12, 2017

Keywords

ClinConnect Summary

Radiotherapy to painful sites of metastasis can provide pain relief.

Side-effects from radiotherapy is dependent on the volume and dose received by normal tissues. Conventional radiotherapy techniques delivers similar doses of radiation to the targeted cancer lesion and the normal tissues along the entrance and exit paths of the radiation.

Volumetric intensity-modulated arc therapy (VMAT) is an advanced technique of radiotherapy that spares normal tissues from receiving high-dose irradiation. However, VMAT increases the volume of normal tissues receiving low-dose irradiation.

This study ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Pain (SF-BPI score ≥1) should be related to metastases (bone or others) or to the tumor itself
• • 2. Capable of providing the full list of analgesic medication being used
• • 3. Capable of completing the SF-BPI and EORTC questionnaires without any help
• • 4. Life expectancy of at least 3 month
• • 5. KPS greater or equal to 50
• • 6. Radiotherapy to 1 site pain
• • 7. Site of treatment not previously irradiated
• • 8. No planned changes in analgesic within 7 days before and after treatment
• • • Patient may be started on Dexamethasone on the first day of radiotherapy
• • 9. No planned chemotherapy, radiotherapy or surgery within 7 days before and after treatment
• • 10. Patient provided informed consent to participate in this study
• Exclusion Criteria:
• • 1. Major mental or psychiatric impairments, which in the investigator's opinion will prevent administration or completion of the protocol therapy and/or interfere with follow-up.
• • 2. Treatment to upper and lower limb
• • 3. Treatment to 2 or more sites of pain
• • 4. Re-irradiation of the site of treatment
• • 5. Women who are pregnant
• • 6. Life expectancy less than 3 month