Impact of Vitamin D Supplementation in Patients With Multiple Sclerosis

Launched by UNIVERSITY MEDICAL CENTRE MARIBOR · Dec 20, 2017

Keywords

ClinConnect Summary

Vitamin D is important risk factor for developing multiple sclerosis (MS) and for disease progression. Patients with MS who had lower vitamin D levels were at increased risk for more clinical attacks and faster disease progression. It was also shown that patients with MS had lower vitamin D levels in serum than healthy controls. It is not clearly defined, which are the levels of vitamin D in serum, that are high enough to trigger immunomodulatory effect and are safe for patients.

This double-blind randomized clinical trial was designed to compare impact of vitamin D supplementation during ...

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ALL

Eligibility criteria

• Inclusion Criteria:
• • Relapsing remitting MS
• • Treatment with immunomodulatory drug
• • Age 18-60 years and
• • EDSS (Expanded Disability Status Scale) score less than 5.
• Exclusion Criteria:
• • Use of vitamin D supplements in the past 3 months
• • Pregnancy, planning pregnancy or nursing
• • Relapse of disease and corticosteroids use in past month
• • Active inflammation at the start of the study (flu, cystitis etc.)
• • Renal disease
• • Elevated levels of calcium or parathormone
• • Hypersensitivity to vitamin D preparations
• • Switching of immunomodulatory drug in past 3 months
• • Other autoimmune disease
• • History of hyperparathyroidism, liver disease, tuberculosis, sarcoidosis or kidney stones