Neuroimaging Biomarkers of Prognosis in Motor Functional Neurological Disorders

Launched by MASSACHUSETTS GENERAL HOSPITAL · Jan 5, 2018

Keywords

ClinConnect Summary

Functional Neurological Disorder (FND) (Conversion Disorder) is a poorly understood and prevalent somatoform disorder, making up 16% of outpatient neurology referrals. Patients with motor FND (mFND) are difficult to treat, result in major morbidity, and are costly to the US. An estimated $256 billion is spent annually treating this population. mFND includes Nonepileptic Seizures (NES), Functional Movement Disorders (FMD) and Functional Weakness (FW). An impediment to managing mFND is the lack of a neurobiological understanding for this disorder. The diagnosis of mFND is currently based on q...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • clinically established motor functional neurological disorder, including individuals with functional movement disorders, functional limb weakness and psychogenic nonepileptic seizures
• Exclusion Criteria:
• • active suicidality
• • major medical/neurological comorbidities with known central nervous system (CNS) consequences
• • active drug use or alcohol dependence
• • known history of a primary psychotic disorder