Defining the Temporal Changes in the Acute Phase Response During Graded Exercise: A Prospective Study

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Jan 5, 2018

Keywords

ClinConnect Summary

Injury, ranging from a paper cut that barely splits the skin to a high-speed motor vehicle accident that rips through muscle and bone, causes a disruption of tissue compartments. This breach of compartments disposes tissue to four principle problems: 1) bleeding, 2) susceptibility to infection, 3) hypoxia, and 4) tissue dysfunction. The acute phase response (APR) is the physiologic system that resolves these four problems of injury. It is divided into two temporally distinct phases: survival and repair. The survival phase utilizes coagulation and inflammation to temporarily seal off breache...

Gender

ALL

Eligibility criteria

• • Arm 1: 20-minute graded exercise Inclusion criteria
• • Healthy individuals (male or female) aged 18-29
• • Regular participation (at least 2 times per week) in moderate intensity exercise
• • BMI between 18.5 and 30.0
• • Exclusion criteria
• • Pre-existing health conditions or injuries that may limit the ability to safely participate in exercise
• • Acute disease process such as an infection, broken bone, or asthma attack
• • Chronic or recent use (within the last 10 days) of any anticoagulant medication or NSAID
• • Pregnant women
• • Recent inpatient admission within the last six months
• • History of smoking or illicit drug use
• • Arm 2: Marathon participation Inclusion criteria
• • Healthy individuals (male or female) aged 18-49
• • In training to complete a marathon (individuals already planning on running a marathon and training accordingly for it)
• • BMI between 18.5 and 30.0
• • Exclusion criteria
• • Pre-existing health conditions or injuries that may limit the ability to safely participate in exercise
• • Acute disease process such as an infection, broken bone, or asthma attack
• • Chronic or recent use (within the last 10 days) of any anticoagulant medication or NSAID
• • Pregnant women
• • Recent inpatient admission within the last six months
• • History of smoking or illicit drug use