IOP Elevation Study

Launched by NYU LANGONE HEALTH · Jan 8, 2018

Keywords

ClinConnect Summary

The IOP Elevation Study is researching how increased pressure in the eye, known as intraocular pressure (IOP), may lead to vision loss in glaucoma. The study aims to better understand the changes in the eye that occur when IOP rises and how these changes can cause damage to important structures in the eye, particularly the optic nerve head (ONH) and the lamina cribrosa (LC). Scientists hope that by learning more about these processes, they can develop better treatments for glaucoma.

To participate in this study, you must be a healthy volunteer or have been identified as a glaucoma suspect or patient. Healthy volunteers should not have a family history of glaucoma and must have normal eye exams. Those with glaucoma suspects may have slightly elevated IOP or differences in eye structure but should still have normal vision tests. Participants can expect to undergo various eye examinations to assess their condition and help researchers gather important data. If you're interested, this study is currently recruiting participants of all genders aged between 65 and 87 years.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Healthy volunteers
• • No family history (first degree relative) of glaucoma.
• • No history of IOP \>22 mmHg.
• • Normal appearing optic discs and RNFL on dilated fundus examination.
• • Normal Swedish interactive thresholding algorithm (SITA) standard perimetry tests as defined by glaucoma hemifield test (GHT) within normal limits.
• • Glaucoma suspects
• • Normal visual field as defined above.
• • Either IOP between 25 to 30 mmHg with central corneal thickness \< 550µm, or a difference ≥ 0.2 in cup to disc ratio between eyes.
• • Glaucoma
• • Glaucomatous ONH abnormality: rim thinning, notching, undermining (excavation) or diffuse or localized RNFL defects that are characteristic of glaucoma.
• • Two consecutive abnormal SITA standard perimetry tests with GHT outside normal limits.
• Exclusion Criteria:
• • Media opacity (e.g. lens, vitreous, cornea).
• • Strabismus, nystagmus or a condition that would prevent fixation.
• • Diabetes with evidence of retinopathy.
• • Previous intraocular surgery or ocular trauma (with the exception of laser procedures and subjects that have undergone uneventful cataract surgery more than 6 months from enrollment date).
• • Neurological and non-glaucomatous causes for visual field damage.
• • Any intraocular non-glaucomatous ocular disorders.