Physiologic and Functional Adaptations of Insulin Sensitive Tissues

Launched by VANDERBILT UNIVERSITY MEDICAL CENTER · Jan 15, 2018

Keywords

ClinConnect Summary

Upper endoscopy (subset)

* Intestinal biopsies will be obtained during scheduled upper endoscopy from the mid-duodenum and/or proximal jejunum. In the case that a patient requires an upper endoscopy after metabolic and bariatric surgery, biopsies will be obtained from the mid-jejunum.
* Blood will be collected from an IV placed in the arm used for administering anesthesia required for the indicated procedure.

Colonoscopy (subset)

* Biopsies of the colon will be obtained during scheduled colonoscopy.
* Blood will be collected from an IV placed in the arm used for administering anesthesia ...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • - Scheduled for upper endoscopy, colonoscopy or metabolic and bariatric surgery, or liver transplantation at Vanderbilt University Medical Center.
• • Additional inclusion criteria for individuals scheduled for metabolic and bariatric surgery: Obese, ≥ 40 kg/m2 or ≥ 35 kg/m2 + one comorbidity (type 2 diabetes \[fasting blood glucose ≥ 120 mg/dL; HbA1C ≥ 6.5%\]; fatty liver disease, hypertension, cardiovascular disease, hyperlipidemia)
• • Additional inclusion criteria for individuals scheduled for liver transplantation: diagnosis of nonalcoholic liver disease or nonalcoholic steatohepatitis
• Exclusion Criteria:
• • Known history of intestinal diseases including, but not limited to, inflammatory bowel disease (e.g. ulcerative colitis, Crohn's disease) and celiac sprue.
• • Smoking \>7 cigarettes per day
• • Malabsorptive syndromes
• • Pregnant or breastfeeding
• Additional exclusion criteria for patients undergoing endoscopy/colonoscopy:
• • Recent history of malignancy (\<5 years ago)
• • Previous lap band surgery
• • Established renal disease
• Additional exclusion criteria for patients undergoing bariatric surgery:
• • Previous lap band, sleeve gastrectomy, or gastric bypass surgery
• • Recent history of malignancy (\< 5 years ago)
• • Established organ dysfunction
• Additional exclusion criteria for patients undergoing liver transplantation:
• • Previous lap band, sleeve gastrectomy, or gastric bypass surgery
• • Alpha 1 anti-trypsin disease, Wilson's disease, viral hepatitis, alcoholic liver disease