Accelerated iTBS for Post Partum Depression

Launched by MEDICAL UNIVERSITY OF SOUTH CAROLINA · Jan 30, 2018

Keywords

ClinConnect Summary

This clinical trial is exploring a new treatment for women experiencing postpartum depression, which is a type of depression that can occur after giving birth. The study involves using a technique called transcranial magnetic stimulation (TMS) to help improve mood. In the first part of the trial, participants will receive this treatment 10 times a day for six days, while in the second part, they will receive it 12 times a day for five days. The goal is to see how well these treatment schedules work and how comfortable participants feel during the process.

To be eligible for this trial, participants must be women over the age of 18 who are experiencing postpartum depression, with symptoms starting within the first year after childbirth. They should have a certain level of depression according to a specific rating scale. However, women who are currently pregnant, have certain mental health issues, or have other serious medical conditions cannot participate. Those who join will receive the TMS treatment in a supportive environment and will be monitored for their progress throughout the study. This trial aims to find effective ways to help women who are struggling with postpartum depression.

Gender

FEMALE

Eligibility criteria

• Inclusion Criteria:
• • 1. Participants must be able to provide informed consent and function at an intellectual level sufficient to allow accurate completion of all assessment instruments.
• • 2. Participants must be over the age of 18.
• • 3. Participants must meet criteria for post-partum depression: a) onset of symptoms in the first year postpartum
• • 4. Participants must have a HRSD17 greater than or equal to 14 at baseline.
• Exclusion Criteria:
• • 1. Participants must not be pregnant.
• • 2. Participants must not meet moderate or severe use disorder of any substance with the exception of Tobacco Use Disorder.
• • 3. Participants must not have current psychotic symptoms.
• • 4. Participants must not have a history of dementia or other cognitive impairment.
• • 5. Participants must not have active suicidal ideation requiring hospitalization or a suicide attempt within the past 3 months.
• • 6. Participants must not have any contraindications to receiving rTMS (e.g. metal implanted above the neck, history of seizure, any known brain lesion).
• • 7. Participants must not have any unstable general medical conditions.
• • 8. Participants must not have had eclampsia during pregnancy.