Antimicrobial and Clinical Efficacy of Cliradex® as Compared With I-Lid'n Lash® Hygiene in Treating Blepharitis

Launched by OTTAWA HOSPITAL RESEARCH INSTITUTE · Jan 30, 2018

Keywords

ClinConnect Summary

Previous studies have shown the clinical and antimicrobial efficacy of eyelid hygiene with tea tree oil (TTO) in resolving chronic blepharitis. This randomized, outcomes-assessor masked, clinical trial aims to determine the efficacy of Cliradex®, which contains the most active ingredient of (TTO), as compared with I-Lid 'n Lash® Hygiene, in treating chronic blepharitis

Blepharitis is a family of inflammatory disease processes of the eyelid. It can be divided anatomically into anterior and posterior blepharitis. Anterior blepharitis refers to inflammation mainly centered around the eyelashe...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Patients with symptomatic blepharitis for duration of at least 3 months.
• • Male and female age range: \> 18 years old.
• • All ethnic groups comparable with the local community.
• • Patients able and willing to cooperate with the investigational plan.
• • Patients able and willing to complete all postoperative follow-up visits.
• • Able to understand and willing to sign a written informed consent.
• Exclusion Criteria:
• • Patients who are currently engaged in another clinical trial.
• • Patients who are unwilling or unable to give consent.
• • Patients who are unwilling to accept randomization.
• • Patients who will not be able to return for scheduled visits.
• • Children under 18.
• • Concomitant use of ophthalmic topical medications (excluding non-preserved tear substitutes).
• • Concomitant use of systemic antibiotics or steroids.
• • Active ocular infection or allergy.
• • Previous surgery on the eyelids such as blepharoplasty.
• • Abraded skin on or around the eyelids.
• • Patients unable to close eyes or uncontrolled blinking.
• • Previous allergic reaction to TTO-containing products or cosmetic fragrance.