Investigating the Genetic Basis of Pseudoexfoliation Syndrome, Angle-closure Glaucoma and Primary Open-angle Glaucoma

Launched by MEDICAL UNIVERSITY OF VIENNA · Feb 5, 2018

Keywords

ClinConnect Summary

This clinical trial is looking into the genetic factors that may increase the risk of developing different types of glaucoma, including pseudoexfoliation syndrome (PXF), primary angle-closure glaucoma (PACG), and primary open-angle glaucoma (POAG). Researchers want to better understand how these genetic traits might affect individuals and help in finding new ways to treat or prevent these conditions.

To participate in this study, you need to meet certain criteria. For example, if you have PXF, you should be at least 50 years old and have a confirmed diagnosis of the condition. If you have PACG, you need to be 21 or older with a confirmed diagnosis as well. Healthy individuals over 60 without any history of glaucoma or other major eye diseases can also join as control participants. Those with POAG should be at least 30 years old and have no signs of other types of glaucoma. Participants will be asked to provide informed consent and may undergo genetic testing as part of the study. This research is still recruiting, and your involvement could contribute to important findings in glaucoma treatment and prevention.

Gender

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Eligibility criteria

• Inclusion Criteria:
• 1. For patients with PXF:
• • Patients with confirmed pseudoexfoliation syndrome (exfoliation glaucoma / pseudoexfoliation of the lens) in the medical history
• • Informed consent
• • Age 50 years or more
• 2. For patients with PACG:
• • Patients with confirmed acute primary angle closure (PAC) or primary angle closure glaucoma (PACG) in the medical history
• • Informed consent
• • Age 21 years or more
• 3. For healthy controls:
• • No evidence of PXF, glaucoma or uveitis during clinical examination or in the medical history
• • No evidence of major ocular disease such as diabetic retinopathy, age related macular degeneration or conditions with genetic background during clinical examination or in the medical history
• • Age more than 60 years
• • Informed consent
• 4. For patients with POAG:
• • Patients with confirmed primary open angle glaucoma (POAG)
• • No evidence of exfoliation glaucoma / pseudoexfoliation of the lens or pigment glaucoma
• • Informed consent
• • Age 30 or more
• Exclusion Criteria:
• * Patients and subjects will be excluded if one or more of the following criteria apply:
• • Neovascular glaucoma
• • Active or history of uveitis
• • Secondary angle closure such as neovascular glaucoma or uveitis/inflammatory eye disease
• • Inability to give informed consent