Biospecimen Procurement for Head and Neck Disorders

Launched by NATIONAL CANCER INSTITUTE (NCI) · Feb 9, 2018

Keywords

ClinConnect Summary

This clinical trial is focused on studying various disorders related to the head and neck, such as hearing problems and certain types of cancers. Researchers aim to collect tissue samples from patients to better understand these conditions and ultimately develop improved treatments. If you are 3 years or older and have had or will have a tissue sample taken due to a head or neck issue, you might be eligible to participate.

Participants will first complete a questionnaire and undergo a physical exam. If you agree to join, your leftover tissue samples from previous medical care may be used for research. If your samples show specific conditions, you may be invited to provide additional samples like blood, saliva, or skin biopsies. These samples will help researchers conduct further studies, including genetic testing. It's a great opportunity to contribute to important medical research that could benefit future patients with similar conditions.

Gender

ALL

Eligibility criteria

• * INCLUSION CRITERIA:
• • Age 3 and older.
• • Able to provide their own consent, or for minors, a parent or guardian is able to consent on their behalf.
• • Diagnosis of a condition of the head and neck for which removal of biological specimens was indicated for clinical care or for research purposes under a separate Review Board (IRB) approved protocol.
• • Ability of subject (or Legally Authorized Representative (LAR)) to understand and the willingness to sign a written informed consent document.
• EXCLUSION CRITERIA:
• * Part 1:
• • --Are unwilling to share waste specimens for research purposes
• * Part 2: Additional exclusion criteria for the Part 2 prospective sample collection part of this protocol these criteria may be assessed prior to collection of the samples but will not affect overall eligibility for the trial (i.e., Part 1):
• • have active symptomatic major organ disorders that would increase the risk of biopsy for research, including but not limited to bleeding disorders, ischemic heart disease, a recent myocardial infarction, active congestive heart failure or severe pulmonary dysfunction
• • have specific medical condition, such as a bleeding tendency where additional biopsies or phlebotomy procedures may increase the participants risk in participating. This will be determined at the discretion of the principal investigator
• • Individuals under the age of 18 are excluded from oral mucosal biopsies and skin biopsies