Phenotyping Asthma for Bronchial Thermoplasty

Launched by MASSACHUSETTS GENERAL HOSPITAL · Feb 14, 2018

Keywords

ClinConnect Summary

This clinical trial is studying a new imaging technology called optical coherence tomography (OCT) to better understand how the airways of patients with severe asthma respond to a treatment called bronchial thermoplasty. This treatment is designed to help people manage their asthma symptoms more effectively. The researchers hope that by using OCT, they will be able to improve the way doctors assess and follow up with patients who receive this treatment in the future.

To participate in this study, you need to be between 18 and 60 years old and undergoing elective bronchial thermoplasty. It's important that you're able to give informed consent and that you have a certain level of asthma severity as determined by specific tests. You should also be a non-smoker and not have any other significant lung diseases. If you choose to join, you can expect to undergo imaging tests before and after your bronchial thermoplasty to see how your airways change with the treatment. This trial is currently recruiting participants, and it could lead to better care for patients with severe asthma in the long run.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Patient undergoing elective bronchial thermoplasty
• • 2. Patient is between the ages of 18 and 60
• • 3. Patient is able to give informed consent
• • 4. Negative pregnancy test for all female of childbearing potential who are sexually active and not using contraception, are seeking to become pregnant, or who are nursing.
• • 5. Nonsmoking (\<5 pack year tobacco exposure)
• • 6. No history of co-existing lung disease
• • 7. Meet American Thoracic Society criteria for diagnosis of asthma with either/or
• • 1. Bronchodilator response to albuterol (≥12% change in FEV1)
• • 2. Positive methacholine bronchoprovocation (PC20 \< 25 mg/ml)
• Exclusion Criteria:
• • 1. Patients who are pregnant.
• • 2. Patient does not meet the requirements to undergo clinical bronchial thermoplasty, as determined by the treating physician