Alternation in the Human Microbiome With Commonly Used Topical Medications

Launched by UNIVERSITY OF CALIFORNIA, DAVIS · Feb 12, 2018

Keywords

ClinConnect Summary

This clinical trial is studying how commonly used creams, like antifungals and low-potency steroids, might change the bacteria and other microorganisms living on our skin, known as the skin microbiome. Specifically, researchers want to find out if using ketoconazole cream, which treats fungal infections, or desonide ointment, a mild steroid for skin conditions, affects the skin microbiome over a short period of time.

To participate in this study, you need to be an adult aged 18 or older and generally healthy. However, people with certain skin diseases, recent use of antibiotics, or known allergies to the medications being tested won’t be eligible. If you join the study, you will use one of the creams and then provide samples to help researchers see if and how your skin microbiome changes. This study is important as it helps us understand the effects of common skin treatments on our skin's natural bacteria, which could lead to better skincare practices in the future.

Gender

ALL

Eligibility criteria

• The inclusion criteria:
• • • Adults at least 18 years of age.
• The exclusion criteria:
• • Individuals with known chronically active skin diseases, including atopic dermatitis, psoriasis, seborrheic dermatitis, other autoimmune and inflammatory skin conditions.
• • Patients with a history of skin cancer, multiple nevi, or other isolated lesions will not be excluded.
• • Individuals who have used topical, intravenous, intramuscular, or oral antibiotics within the last 6 months
• • Individuals with known allergies to any of the study medications.
• • Individuals younger than 18 years of age.
• • Adults unable to consent
• • Non-English speaking individuals. Given the complexity in the instructions that subjects will need to follow for proper sample collection, we will not seek to recruit non-English speaking individuals for this pilot study.
• • Prisoners