Assessment of Stroke Volume and Cardiac Output in Response to Varying Heart Rates
Launched by UNIVERSITY OF CALGARY · Feb 22, 2018
Trial Information
Current as of November 08, 2025
Recruiting
Keywords
ClinConnect Summary
This clinical trial is looking at how changing heart rates affects the heart's ability to pump blood, specifically focusing on stroke volume (the amount of blood the heart pumps with each beat) and cardiac output (the total amount of blood the heart pumps in a minute). The researchers will work with patients who have permanent pacemakers, which are devices that help control heart rhythm. This makes it safe for them to adjust heart rates without any invasive procedures.
To participate in the study, individuals need to be between 18 and 70 years old and have a permanent pacemaker or an implanted defibrillator that can change heart rates. It's important that their heart's pumping ability is functioning well, with a measurement called left ventricular ejection fraction above 50%. Participants will undergo non-invasive tests to monitor how their heart responds to these changes in heart rates. If you or someone you know meets these criteria and is interested in understanding more about how heart rates affect heart function, this trial could be an opportunity to contribute to important research in this area.
Gender
ALL
Eligibility criteria
- Inclusion Criteria:
- • Age 18-70 years (inclusive)
- • Implanted permanent pacemaker or implanted defibrillator capable of atrial and ventricular pacing
- • LV ejection fraction \>50%
- Exclusion Criteria:
- • Unable or unwilling to provide informed consent
- • Clinical need for a cardiac resynchronization device
About University Of Calgary
The University of Calgary is a leading research institution dedicated to advancing health and science through innovative clinical trials. With a strong emphasis on multidisciplinary collaboration, the university's clinical research initiatives aim to address pressing health challenges and improve patient outcomes. The institution fosters a robust environment for academic inquiry, leveraging state-of-the-art facilities and a diverse network of experts in various fields. Committed to ethical research practices and community engagement, the University of Calgary strives to translate scientific discoveries into tangible benefits for society.
Contacts
Jennifer Cobb
Immunology at National Institute of Allergy and Infectious Diseases (NIAID)
Locations
Calgary, Alberta, Canada
Patients applied
Trial Officials
Satish R Raj, MD MSCI
Principal Investigator
University of Calgary
Timeline
First submit
Trial launched
Trial updated
Estimated completion
Not reported
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