The Minimally Invasive Coronary Surgery Compared to STernotomy Coronary Artery Bypass Grafting Trial

Launched by OTTAWA HEART INSTITUTE RESEARCH CORPORATION · Feb 21, 2018

Keywords

ClinConnect Summary

The MIST Trial is studying two methods of heart surgery for patients with coronary artery disease, a condition where blood vessels in the heart become blocked. One method is called Minimally Invasive Coronary Surgery (MICS CABG), which uses a small cut in the chest to perform the surgery. The other is conventional sternotomy CABG, which involves a larger incision down the middle of the chest. The goal of the trial is to see which method helps patients recover faster and improves their quality of life after surgery.

To participate in this trial, you need to be at least 18 years old and have significant blockages in your coronary arteries that require surgery. If you are chosen, you will complete quality of life questionnaires at different points after your surgery to help researchers understand how you are feeling and recovering. It's important to know that this study is currently recruiting participants, and your involvement could contribute to better treatment options for future patients.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 18 years of age or older
• • Angiographically-confirmed multi-vessel coronary artery disease lesions with \>=70% in at least 2 major epicardial vessels in 2 or more coronary artery territories (left anterior descending (LAD), circumflex (CX) and right coronary artery (RCA)) OR lesions \>=50% in the left main (LM)
• • Patients who, in the opinion of the investigator, are amenable for coronary surgery through either median sternotomy or minimally-invasive approach.
• • Patients who are willing and able to comply with all follow-up study visits.
• Exclusion Criteria:
• • \<18 years of age
• • concomitant cardiac procedure with CABG (e.g. valve repair or replacement)
• • Previous cardiac surgery, mediastinal irradiation, or significant trauma to the chest
• • Contra-indications for MICS CABG, including: severe pectus excavatum; severe pulmonary disease; hemodynamically significant left subclavian stenosis; morbid obesity; severe left ventricular (LV) dysfunction; no adequate PDA or marginal branch target; absence of femoral pulse bilaterally.
• • Contraindications for conventional CABG via sternotomy
• • Concomitant life-threatening disease likely to limit life expectancy to \<2 years
• • Emergency CABG with hemodynamic compromise
• • Inability to provide informed consent.