Exploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung Disease

Launched by MCMASTER UNIVERSITY · Feb 28, 2018

Keywords

ClinConnect Summary

This clinical trial is studying a special type of MRI called hyperpolarized xenon-129 (129Xe MRI) to learn more about how healthy lungs work compared to those with various lung diseases like asthma, COPD, and pulmonary fibrosis. The researchers aim to understand lung structure and function better, which could help in assessing how well treatments are working for patients with these conditions.

To participate, you must be between 18 and 85 years old and either have a diagnosed lung disease or be a healthy volunteer without any history of respiratory issues. Participants will undergo 129Xe MRI scans, which are safe and non-invasive, to evaluate lung health. The study is currently looking for volunteers, so if you or someone you know fits the criteria and is interested, you can reach out to learn more about joining this important research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria for participants with lung disease:
• • Male or female aged 18-85 years with diagnosed lung disease including but not limited to: asthma, emphysema, COPD, bronchiectasis, sarcoidosis, pulmonary fibrosis, alpha 1-anti-trypsin deficiency, eosinophilic granulomatosis with polyangiitis and bronchopulmonary dysplasia.
• • Subject understands the study procedures and is willing to participate in the study as indicated by the signature on the informed consent
• • Subject is judged to be in otherwise stable health on the basis of medical history
• • Able to read and/or understand English
• • Have a diagnosis of lung disease
• Inclusion Criteria for healthy volunteers:
• • Subjects male or female aged 18-85 years
• • Subject understands the study procedures and is willing to participate in the study as indicated by the signature on the informed consent
• • Subject is judged to be in otherwise stable health on the basis of medical history
• • Able to read and/or understand English
• • No current or previous history of respiratory infection or disease
• Exclusion Criteria:
• • Age \< 18 years or \>85 years
• • Pregnancy prior to or during study
• • In the opinion of the investigator, subject is mentally or legally incapacitated, preventing informed consent from being obtained, or cannot read or understand the written material
• • Patient is unable to perform spirometry or plethysmography maneuvers
• • Patient has an implanted mechanically, electrically or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants) (at the discretion of the MRI Technologist/3T Manager)
• • In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, such as severe claustrophobia
• Exclusion Criteria for healthy volunteers only:
• • Current or previous history of respiratory infection or disease
• • Current smoker or ex-smoker with ≥10 pack-year history