Therapeutic Effects of Endoscopic Ablation of Hunner Lesions in Interstitial Cystitis/ Bladder Pain Syndrome Patients

Launched by SAMSUNG MEDICAL CENTER · Mar 11, 2018

Keywords

ClinConnect Summary

This clinical trial is studying the effects of a procedure called endoscopic ablation on patients who have Hunner lesions, a specific type of tissue change often seen in individuals with Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS). The goal is to see how effective this treatment is in reducing pain and improving symptoms over the long term for those who have been suffering for at least six months.

To participate in the trial, you need to be at least 18 years old and diagnosed with Bladder Pain Syndrome, experiencing significant pain and other symptoms. You should not have had certain prior treatments or surgeries related to your bladder condition in the last two years. If you join the trial, you can expect to receive the endoscopic ablation treatment and will be monitored closely for changes in your symptoms over time. This study is currently looking for participants of all genders, and it's an opportunity to potentially help improve your condition while contributing to important medical research.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • 1. Male and female aged 18 yrs or greater
• • 2. Patients diagnosed with BPS(Bladder Pain Syndrome)
• • 3. Symptom persisted more than 6 months
• • 4. Pain VAS ≥4
• • 5. O'Leary-Sant Interstitial Cystitis questionnaire (IC-Q) scores 12 or greater with pain and nocturia domain scores \> 2.
• • 6. Pelvic Pain and Urgency/Frequency Patient Symptom Scale(PUF) \>13
• • 7. No history of cystoscopy within 2yrs.
• Exclusion Criteria:
• • 1. History of augmentation cystoplasty or previous transurethral coagulation/resection due to BPS
• • 2. Child-bearing potential, pregnant or nursing women.
• • 3. Mean voided volume lesser than 40ml or over than 400ml.
• • 4. Hematuria exceeds 1+ in the urinary dipstick (dipstick) examination.
• • 5. Urinary tract infection during run-in periods.
• • 6. Genitourinary tuberculosis or bladder,urethral and prostate cancer
• • 7. Recurrent urinary tract infection
• • 8. History of hysterectomy,mid-urethral sling,pelvic organ prolapse repair,vaginal delivery or Cesarean section,prostate operation or treatment etc within 6months.
• • 9. Neurologic disease history of cerebral infarction,multiple sclerosis or parkinsonism etc.-