The Influence of Bone Allograft Particle Sizes on the Quantity and Quality of New Bone Formation in Grafted Extraction Sockets and Edentulous Ridges

Launched by UNIVERSITY OF ALABAMA AT BIRMINGHAM · Mar 12, 2018

Keywords

ClinConnect Summary

This study is a prospective, two-arm, randomized trial that will evaluate and compare the bone healing following ridge preservation of extraction sockets (RP, Arms 1 and 2) or lateral ridge augmentation of edentulous sites (RA, Arms 3 and 4) using either small particle (SP) or large particle (LP) mineralized cortico-cancellous bone allografts in a total of 48 patients (12 in each arm).

Study approval was obtained from the university's institutional review board. Qualifying participants and defects are randomized following a computerized permutation block to receive either LP or SP allograf...

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • English speaking
• • At least 18 years old
• • Must be a patient of the UAB Dental School
• • Able to read and understand informed consent document
• • Need for implants to replace missing tooth or teeth in at least one quadrant of the mouth.
• • Hopeless tooth or teeth planned to be replaced with dental implant(s)_socket with residual 4 walls following minimally invasive tooth extraction (a dehiscence of \<3mm may be included) or insufficient alveolar ridge width for endosseous implant placement defined as 5mm or less as determined by bone sounding and cone beam computed tomography (CBCT) scan.
• • Patient and/or guardian is willing and able to comply with the preoperative and postoperative diagnostic and clinical evaluations required.
• Exclusion Criteria:
• • Non-English speaking
• • Less than 18 years old
• • Smokers/tobacco users (\>10 cigarettes/day)
• • Patients with systemic pathologies or conditions contraindicating oral surgical procedures or adversely affecting wound healing
• • Patients with significant medical conditions or habits expected to interfere with bony healing.
• • Patient is a poor compliance risk (i.e., poor oral hygiene, history of alcohol or drug abuse)
• • Bone dehiscence of \>4mm following tooth extraction or Vertical loss of bone at edentulous ridge