A Randomized Controlled Study Evaluating Bariatric Surgery as a Treatment for Severe NASH With Advanced Liver Fibrosis in Non-severe Obese Patients

Launched by UNIVERSITY HOSPITAL, LILLE · Mar 13, 2018

Keywords

ClinConnect Summary

This clinical trial is studying the effects of bariatric surgery, a type of weight-loss surgery, on patients with severe nonalcoholic steatohepatitis (NASH) and advanced liver fibrosis. The goal is to see if this surgery can help improve liver health better than standard medical treatments. The trial is looking for adults aged 18 to 75 with obesity (a body mass index, or BMI, between 30 and 50) and advanced liver fibrosis, which means there is significant scarring in the liver.

To participate, individuals must provide consent and meet specific health criteria, including having a recent liver biopsy confirming their condition. Participants will need to undergo one liver biopsy before the surgery and another at the end of their treatment to evaluate the effects of the surgery. Those who qualify can expect regular visits to monitor their progress throughout the study. It’s important to note that certain medical conditions and previous surgeries may exclude individuals from participating, so anyone interested should discuss their eligibility with a healthcare provider.

Gender

ALL

Eligibility criteria

• Inclusion Criteria:
• • Provide written informed consent and agree to comply to the study protocol prior to enrolment.
• * BMI and Brunt Fibriosis score:
• • For F3 fibrosis patients: 35\>BMI≥ 30kg/m² ; Fibroscan ≥ 9kPa or FibrometreVM ≥0.526 predicting a F3 fibrosis score grade within 1 month before inclusion or F3 fibrosis score grade diagnosed by hepatic biopsy performed before inclusion.
• • For F4 fibrosis patients: 50\>BMI≥ 30kg/m² ; Fibroscan ≥ 15kPa predicting a F4 fibrosis score grade within 1 month before inclusion or F4 fibrosis score grade diagnosed by hepatic biopsy performed before inclusion.
• • Fibroscan ≥ 9kPa or FibrometreVM ≥0.526 predicting a F3 or F4 fibrosis score grade within 1 month before inclusion Or F3 or F4 fibrosis score grade diagnosed by hepatic biopsy performed before inclusion.
• • Patient should agree to have one liver biopsy during the screening period (before randomization, the randomization will be permitted after at least a second reading performed by pathologist of CHRU Lille to confirm the histological diagnosis of NASH with advanced fibrosis (F3-F4)) for the diagnosis purpose (if no histological biopsy within 1 month before inclusion is available) and one at the end of the treatment period for assessment of the treatment effects.
• • For patients with cirrhosis, patients must fulfil all the following criteria: Platelets \> 125 000, PT \> 80 %, Albumin \> 35 g/L, MELD score at inclusion \< 9, CPT score \< 6, No history of previous decompensation, No oesophageal varices (endoscopy), No vascular shunt, ASA score ≤ III, Alcohol consumption lower than 20g/day for women and 30g/day for men.
• • For hypertensive patients, hypertension must be controlled by stable dose of anti-hypertensive medication for at least 2 months prior to screening (and the stable dose can be maintained throughout the study).
• • Female participating in the study must be either of non-child bearing (surgically sterilized at 6 month prior to screening or postmenopausal) or using an efficient contraception: hormonal contraception (including patch, contraceptive ring etc) intra-uterine device or other mechanical contraception
• • Patient agrees to come to the study visits within the protocol-specified delay
• Exclusion Criteria:
• • Previous history of bariatric surgery (except gastric ring removed for more than 3 years).
• • Decompensated cirrhosis (MELD\> 7 CPT score\> 5, previous history of decompensation (encephalopathy, ascites, jaundice, varicose vein rupture)
• • Hepatocellular carcinoma
• • Platelets \<125 000; TP \<80%; bilirubin \<20 mmol / l; albumin \<35 g / L.
• • Other liver disease: alcohol consumption exceeding 20 g / day for women and 30g / day in men, HBV, HCV, CBP, CSP, autoimmune hepatitis, hemochromatosis, Wilson's disease, alpha-1 antitrypsin.
• • Being processed Cancer (chemotherapy, radiotherapy or hormone therapy)
• • HIV positive patients
• • Patients who had an acute cardiovascular episode, coronary Heart Disease (Angina pectoris, myocardial infarction, revascularization procedure), stroke or TIA (Transient Ischemic Attack) within the 6 months prior to screening Recent cardiovascular events (stroke, myocardial infarcts, etc...) in the past 6 months.
• • Severe chronic respiratory disease.
• • Severe chronic cardiac insufficiency (grade III and IV of NYHA classification).
• • Pregnant or breastfeeding women.
• • Simultaneous enrollment in another clinical trial.
• • Drug abuse within the past year.
• • Patient with contra-indication for bariatric surgery
• • Gastic Banding, Biliopancreatic diversion and all the new bariatric surgery techniques are forbidden because the study design allow only the laparoscopic sleeve gastrectomy or laparoscopic Roux-en-Y gastric Bypaass.
• * History of cancer, except:
• • Patients considered in remission for at least 5 years after onset of treatment.
• • Patients Treated and believed to be cured basal or squamous cell carcinoma of the skin or resected carcinoma of the cervix