Upright MRI for Prostate Cancer Screening

Launched by ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · Mar 16, 2018

Keywords

ClinConnect Summary

This clinical trial, called "Upright MRI for Prostate Cancer Screening," is looking at a new way to check for prostate cancer using a special type of MRI scan while sitting upright. Researchers want to see if this upright MRI is better at finding prostate cancer than the usual methods, like blood tests for prostate-specific antigen (PSA) and standard MRI scans. The study will take place at Mount Sinai Hospital and will last about five years, focusing on men who are at risk for prostate cancer.

To participate, men need to be at least 18 years old and have been advised by a doctor to get a prostate MRI due to raised PSA levels or other signs. Participants will undergo both the upright MRI and a standard MRI and will be asked how comfortable they felt during the scans. After the scans, they will be followed up every six months for five years to monitor their health. It's important to note that certain conditions or previous treatments may prevent someone from joining the study, so eligibility will be carefully assessed by a doctor.

Gender

MALE

Eligibility criteria

• Inclusion Criteria:
• • Men at risk of prostate cancer and have been advised to have a prostate MRI.
• • Age ≥ 18 years.
• • Fit for undergoing all study protocol procedures which includes an ultrasound guided biopsy.
• • Able to tolerate general or spinal anesthesia.
• • Ability to understand and the willingness to sign a written informed consent and to comply with the protocol.
• Exclusion Criteria:
• • Patients who have been treated using 5- alpha-reductase inhibitors at the time of study enrollment or 6 months prior to enrollment.
• • Patients with previous history of prostate biopsy, prostate surgery or treatment for prostate cancer (interventions for benign prostatic hyperplasia/bladder outflow obstruction is acceptable)
• • Patients who have evidence of a urinary tract infection or history of acute prostatitis within the last 3 months.
• • Patients contraindicated to undergoing the MRI procedure e.g. pacemaker, estimated GFR\<=50, automatic implantable cardiac defibrillators.
• • History of any other medical condition precluding procedures described in the protocol