New Non-invasive Modalities for Assessing Retinal Structure and Function

Launched by RANDY KARDON · Mar 16, 2018

Keywords

ClinConnect Summary

This clinical trial is exploring a new technology that helps doctors look at the inside of the eye to understand how well it is working. The focus is on patients who have specific eye conditions, such as Ischemic Optic Neuropathy or Leber Hereditary Optic Neuropathy, which can cause vision problems. By using advanced imaging techniques, researchers hope to find areas in the retina (the light-sensitive layer at the back of the eye) that may be damaged or not functioning properly. They are looking for a total of 450 participants, including 50 healthy individuals for comparison.

To be eligible for this study, participants with eye conditions need to have a specific type of damage to their retina, while those in the control group must have had a normal eye exam in the last two years. Everyone will need to have a clear view of their retina, meaning that any significant cataracts or other eye problems that could interfere with imaging need to be ruled out. Participants can expect to undergo non-invasive imaging tests, which means they won't require surgery or any uncomfortable procedures. The goal of this research is to improve how doctors assess and understand eye diseases, which could ultimately lead to better treatments and care for patients.

Gender

ALL

Eligibility criteria

• Controls:
• Inclusion:
• • Normal eye exam in last 2 years
• Exclusion:
• • Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay. Any abnormalities of the retina or optic nerve that could affect metabolism of the retina outside of normal.
• Subjects with Inner Retina Defect:
• Inclusion:
• • Defined structural defect to include those with Ischemic optic neuropathy, branch retinal artery occlusion (BRAO), hemianopia or visual field defect that respects the vertical meridian, inherited mitochondrial optic neuropathies such as Leber's and Dominant Optic Neuropathy, other retinopathies or optic neuropathies.
• Exclusion:
• • Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
• Subjects with Outer Retinal Defect:
• Inclusion:
• • AZOOR (acute zonal occult outer retinopathy) or other focal or diffuse outer photoreceptor loss of function
• Exclusion:
• • Cataract or media opacity that would degrade the imaging of the retina. Mild cataracts are okay.
• • The 450 total is to allow for exclusion of some subjects or in the event that the enrolled subject blinks too much or cannot fixate on a visual target adequately to maintain the same eye position during the short imaging interval. We hope to have a total of 450 (50 controls and 400 patients)